Body composition
Tesamorelin Dosage: The 2 mg Belly-Fat Number
A rare peptide with a clear dose and real trials, aimed at deep belly fat.
The quick version
- A GHRH analog that targets deep visceral belly fat. FDA approved.
- Cut visceral fat about 15 percent in 26 weeks, and it returns if you stop.
- Unusually clear dose: 2 mg a day, under the skin, at night.
What it is
Tesamorelin is a GHRH analog that tells the body to release growth hormone. It is FDA approved as Egrifta for visceral fat in people with HIV. People also use it off label to target deep belly fat.
What the research shows
The trial data is specific. In a 412-person randomized trial, 2 mg of tesamorelin per day cut visceral fat by about 15 percent in 26 weeks, while placebo rose about 5 percent (Falutz et al., 2007). The catch: the fat returned after stopping, so the effect needs ongoing use. It hits the deep abdominal fat, not the fat you can pinch.
What it felt like
I have not run a long tesamorelin cycle myself, so I am leaning on the trial data here rather than my own log. The people I have seen use it cared about visceral fat specifically, not scale weight.
Dosing reality
The approved dose is 2 mg injected under the skin once a day, usually at night on an empty stomach. That label number is unusually clear for this space, which is one reason I trust the data more than most.
The one mistake to avoid
The mistake is expecting tesamorelin to drop scale weight like a GLP-1. It reshapes deep fat over months. If your goal is appetite control and big weight loss, this is the wrong tool.
Bottom line
Tesamorelin is one of the few peptides here with a clear dose and real trials, but it is a visceral-fat tool, not a general weight-loss one.
Sources
Reminder: I am not a doctor and this is not medical advice. It is my own notes and reading of the research. Peptides sit in a legal grey area, research-grade is a real category, and it is on you to verify your own compliance. Talk to a qualified professional before you start anything, especially if you take other medication.